Creatinine is a substance produced by vertebrates, and it shows up in urine. If someone substitutes their urine with something other than urine, like Mountain Dew, they will test negative for drugs. However the testee will most likely not get away with it because Mountain Dew contains zero creatinine, and labs test creatinine levels to ensure that the sample is valid. Creatinine levels drop below normal when people dilute their urine. This tests to ensure that the subject did not drink unusual amounts of water. An *accurate* creatinine "clearance" test would require a urine and blood test 24 hours before the drug test to determine the normal creatinine level for that individual. This is almost never done. You should still be cautious because they do often use the inaccurate method of comparing your creatinine level during the drug test to an average. People who are drug-free sometimes lose their jobs for having too low of a creatinine level.

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