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As a derivative of phenothiazine, promethazine is structurally and pharmacologically similar to chlorpromazine. It exhibits strong antihistamine activity as well as expressed action on the CNS. It potentiates action of sedative and analgesic drugs.

Promethazine is used for treating allergic illnesses such as hives, serum disease, hay fever, dermatosis, and also for rheumatism with expressed allergic components, for allergic complications caused by antibiotics and other medicinal drugs, and for enhancing action of analgesics and local anesthetics. Synonyms of this drug are allergen, phenergan, pipolphen, prothazine, and others.

Trimeprazine: Trimeprazine, 10-(3-dimethylamino-2-methylpropyl) phenothiazine (16.1.19), is synthesized by alkylating phenothiazine with 1-dimethylamino-2-metyl-propylchloride [38].

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