Other Neuroleptics

Sulpiride: Sulpiride, N-[(1-ethyl-2-pirrolidinylmethyl]-5-sulfamoyl-0-anizamide (6.7.2), is synthesized from 5-aminosulfosalycilic acid. Methylating this with dimethylsulfate gives 2-methoxy-5-aminosulfonylbenzoic acid (6.7.1), which is transformed into an amide using 2-aminomethyl-1-ethylpyrrolidine as amine components and carbonyl-1,1'-to-imidazole as a condensing agent [70-74].

Sulpiride possesses moderate neuroleptic activity along with some stimulating and antidepressant effects. It has antiemetic, moderately cataleptogenic, and antiserotonin action. It facilitates increased blood flow in the stomach. It speeds up the restorative processes in tissues. It is used for schizophrenia, depression, migraines, disturbance of behavioral functions, and stomach and duodenal ulcers. Synonyms of this drug are arminol, dogmatil, confidan, eglonil, and many others.

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