Oh

'CH3 cooc2h5

H O CH2Cl

OH OH

C2H5OOC o ^ V COOC2H5 HOOC ^O'

Cromolyn stabilizes the membranes of mast cells, stopping the release of allergy mediators and suppressing activation of eosinophiles, neutrophilis, thrombocytes, and macrophages, which take part in the formation of bronchospasms.

Cromylyn differs from the majority of medications taken for obstructive diseases of the respiratory tract in that it is used only as a preventative agent.

It is used for bronchial asthma, as well as prevention of seasonal, constant, and physically caused asthma attacks and allergic rhinitis. Synonyms of this drug are intal, opticrom, allergospasmin, lomuren, and many others.

23.3.4 Corticosteroids

Many corticosteroids are used as inhalation drugs for bronchial asthma.

Corticosteroids are not bronchodilators, and it is reasonable to think that their action is simply relayted to the anti-inflammatory immunodepressive effect of corticosteroids, which is quite positively manifested in the course of relieving bronchial asthma.

They are widely used for obstructive diseases of the respiratory tract; however, they are not used for severe bronchial asthma attacks.

A number of side effects cased by their systematic use limit their use to some degree as drugs for treating bronchial asthma.

In obstructive pulmonary diseases, drugs mainly used are prednizolone (27.1.33), methyl-prednizolone (27.1.38), dexamethazone (27.1.51), beclomethazone (23.3.10), and flunizolide (23.3.11), the synthesis and detailed description of which will be discussed in Chapter 27.

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