Oco

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H5C2OOC CH 2 N CH2 COOC2H5

According to the next scheme, synthesis of cocaine starts from tropanone, which undergoes methoxycarbonylation with dimethylcarbonate in the presence of sodium, forming the sodium salt (2.1.14), which after the cautious acidic hydrolysis and reduction of the carbonyl group of the resulting ketoester (by sodium amalgam or electrolytically) is ester-ified by benzoylchloride, giving the desired product [8].

1. h2co3

1. h2co3

As in the previous example, the final product is a racemate from which the levorotary isomer is isolated. Other methods of synthesis were suggested later on [9,10].

Cocaine is only used in exceptional cases as a topical anesthetic in ophthalmology due to the fast onset of addiction and its powerful effect on the CNS.

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