O

C _c2h5

3.1.63 fentanyl

CH2OCH3 O

IT! ^CH2OCH3

N-C-C2H5

alfentanil sufentanyl

The synthesis of these compounds will be described in Section 3.1, Opioid analgesics. Besides opioids, benzodiazepines (diazepam, lorazepam, and midazolam), which have anxiolytic, sedative, and anticonvulsant effects, that cause amnesia and muscle relaxation, are frequently used to relieve patients' anxiety during anesthesia.

diazepam lorazepam midazolam diazepam lorazepam midazolam

Synthesis of the first two is described in Section 5.1 of Chapter 5. Benzodiazepines are described in the same place where the synthesis of structural analogs of midazolam (alpra-zolam, etc.) are described.

Since general anesthetics are related to a variety of classes of chemical compounds, there is no general pattern that exists between their chemical structure and their activity. Particular patterns only exist for different groups of compounds (barbiturates, benzodiazepines, etc.).

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