Ampicillin has a broad spectrum of action and is effective for infections caused by various sensitive organisms; it is active with respect to Gram-positive and Gram-negative cocci, intestinal bacilli, salmonella, shigella, enterococci, listeria, and a few strains of hemophilic bacilli. Ampicillin is the drug of choice for infections caused by beta-lactamase negative types of Haemophilus influenzae, Listeria monocytogenes, and enterococci. It is used for bronchitis, pneumonia, dysentery, salmonella, whooping cough, pyelonephritis, endocarditis, sepsis, and so on. Synonyms of this drug are amblocin, binotal, liucipen, totapen, amfipen, ampicil, penberin, and many others.
Amoxycillin: Amoxycillin, [2^-[2a,5a,6^(5)]]-3,3-dimethyl-7-6-[[amino-(4-hydroxyph-enyl)-acetyl]amino]-4-thia-1-azabicyclo[3.2.0]-heptan-2-carboxylic acid (18.104.22.168), is synthesized in two ways. The first uses an enamine protection of the amino group of 4-hydroxyphenylglycine, which begins with the sodium salt of 4-hydroxyphenylglycine, which is reacted with the acetoacetic ester to form an enamine—the sodium salt of a p-hydroxyphenyl acetic acid, a-[(3-ethoxy-1-methyl-3-oxo-1-propenyl)amino]-4-hydroxy-(22.214.171.124). Reacting the resulting aminocrotonate with the ethyl chloroformate in N-methylmorpholine gives the corresponding mixed anhydride (126.96.36.199), which is reacted with trimethylsilyl ester of 6-APA [38,39].
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