Oxymorphone is approximately 10 times more active than morphine. Euphoric effects as well as vomiting are expressed significantly stronger than in morphine. Oxymorphone also displays poor antitussive activity.

Side effects are analogous to those of morphine. It is intended for relieving moderate to severe pain in surgical and gynecological interventions and for post-operational pain.

Oxycodone: The synthesis of oxycodone, 4,5-epoxy-3-methoxy-14-hydroxy-N-methyl-6-oxomorphinane (3.1.25), from 14-hydroxycodeinone (3.1.24) was described above. It can also be synthesized in other ways; for example, by the oxidation of codeine using sodium dichromate in acetic acid [17], and is also a structural analog of morphine and codeine.


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