O

oxidized by various oxidizers such as oxygen or hydrogen peroxide in alkaline or chromic acid in acetic acid into chlorothalidone (21.3.26) [51,52].

NaOH/O2 or

NaOH/O2 or

In terms of activity, chlorothalidone is very similar to benzothiadiazide (21.3.13) and is used as an independent drug or in combination with other antihypertensive agents for lowering arterial blood pressure, and also as an adjuvant drug for treating edema caused by cardiac insufficiency and renal irregularities, including nephrotic syndrome. Synonyms of this drug are gigroton, novatalidon, uridon and others.

Indapamide: Indapamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (21.3.33), is synthesized from 2-methylendoline, the nitrosation of which gives 2-methyl-1-nitrosoindoline (21.3.31). Reducing this with lithium aluminum hydride leads to formation of 1-amino-2-methylendoline (21.3.32). Acylating this with 3-sulfonylamino-4-chlor-benzoic acid chloride leads to (21.3.33) [53,54].

ch3 so2nh2

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