O

CH2C00H

CH3C00Na/

Like coumarin derivatives, phenindione, a compound of the indandione class, acts by altering biosynthesis of coagulant proteins in the liver. It is used for preventing and treating thrombosis, thrombophlebitis, and thromboembolism. However, because of a number of side effects such as polyurea, polydipsia, tachycardia, and others, it is rarely used in practical medicine. Synonyms of this drug are pindone, bindan, gevulin, indan, phenyline, and rectadione.

Anisindione: Anisindione, 3-(p-methoxyphenyl)indan-1,3-dion (24.2.11), differs from phenidione only in the presence of a p-methoxy group in the phenyl ring, and it is synthesized in the same manner as phenindione, but by using p-methoxybenzaldehyde or p-methoxyphenylacetic acid [30-32].

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