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Etoposide is used for germinogenic tumors, ovarian, stomach, and lung cancer, Hodgkin's disease, and non-Hodgkin's lymphoma for both monotherapy and in combination therapy. Synonyms of this drug are vepesid and others.

Teniposide: Teniposide, [5R-(5o,5a/i,8aa,9^)]-9-[4,6-0-(2-thienylmethylene)-/i-D-glucopy-ranosyl)oxy]- 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4': 6,7]-naph-tho[2,3-d]-1,3-dioxol-6(5a#)-one (30.4.9), is basically synthesized by an analogous scheme from 4'-benzyloxy-4'-desmethylepipodophyllotoxin (30.4.6), which is esterified by 2,3,4,6-tetra-O-acetyl-^-D-glucose in the presence of boron trifluoride etherate, giving a glycoside 30.4.7. The acetyl and benzyloxycarbonyl protecting groups in this molecule are removed by succesive use of zinc acetate and sodium methoxide, and then by subsequent hydrogen reduction, which forms the diol 30.4.8. The resulting diol is then transformed into the corresponding acetal 2-formylthiophene, which is the desired teniposide (30.4.9) [128-132].

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