Nh

CH3O ch3o ii

Na }=\ COOC2H5 H2N NH2 CH3O^^ CH2-CH2-COOC2H5 + HCOOC2H5 -CH3O ^ CH2 0H -»"

All of the other syntheses begin with 3,4,5-trimethoxybenzaldehyde. According to one of them, condensation of 3,4,5-trimethoxybenzaldehyde with 3-ethoxy- or 3-anilinopropionitrile gives the corresponding benzylidene derivative (33.1.52), which upon direct reaction with guanidine gives trimethoprim [48-51].

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