In terms of antibacterial spectrum, oxytetracycline is similar to chlorotetracycline. It also belongs to the group of short-lasting tetracyclines, and is used for the same indications as chlorotetracycline. Synonyms of oxytetracycline are acromycin, bicyclin, cyclopar, sarco-cyclin, and many others.
Demeclocycline: Demeclocycline, 7-chloro-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahy-dro-3,6,10,12,12a-pentahdroxy-1,11-dioxo-2-napthacencarboxamide (32.3.4), is produced by a mutant strain of S. aureofaciens, in which the mechanism of transferring methyl groups is disrupted, and thus demeclocycline or demethylchlorotetracycline differs from chlorote-tracycline, oxytetracycline, and tetracycline in the absence of a methyl group at C6 of the hydronaphthacene system. As a result, an antibiotic is synthesized that is more resistant to acids and bases in comparison with the methyl homologs [215-221].
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