As an a-adrenoblocker, ergotamine exhibits a direct vasoconstricting effect for which it is used in medicine, particularly for alleviation of severe migraine attacks. It is categorically counterproductive in chronic diseases because of the possibility of side effects such as triggering gangrene. Synonyms of this drug are synergan, secotamine, and others.
Ergonovine: Ergonovine, 1-hydroxymethylethylamide lysergic acid (12.2.15), is synthesized by esterification of d-lysergic acid using 2-aminopropanol in dimethylformamide and direct treatment of the reaction mixture with phosgene [53-59].
Ergonovine does not exhibit significant a-adrenoblocking activity. However, like ergota-mine, it is used in gynecological-obstetrical practice for stopping postnatal bleeding. The most likely mechanism of action is the direct spasmogenic effect on the uterus. Synonyms of ergonovine are ergometrine and ergotren.
Was this article helpful?