Action of this drug is similar to that of acetazolamide, and it is used for lowering intraocular pressure in treating wide-angle and secondary glaucoma, and before surgical intervention for severe wide-angle glaucoma. Synonyms of this drug are naptazane and others.

Dichlorphenamide: Dichlorphenamide, 4,5-dichlorbenzol-1,3-disulfonamide (21.2.6), is made in a relatively simple way from 2-chlorophenol. 2-Chlorophenol undergoes sul-fochlorination by chlorosulfonic acid, forming 4-hydroxy-5-chlorobenzol-1,3-disulfonylchloride (21.2.4). The hydroxyl group is replaced by a chlorine atom using phosphorous pentachloride, giving 4,5-dichlorobenzol-1,3-disulfonylchoride (21.2.5), the reaction of which with ammonia gives the desired dichlorphenamide (21.2.6) [8].


SO2-Cl SO2-NH2

SO2-Cl SO2-NH2

Like the drugs described above, dichlorphenamide is used for secreting excess water in cases of elevated intraocular pressure, and it is used for treating wide-angle and secondary glaucoma as well as in cases where it is necessary to lower intraocular pressure before surgical intervention in severe wide-angle glaucoma. Synonyms of this drug are daranide and others.

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