Gallamine is used for the same indications as tubocurarine. A synonym of this drug is flaxedil.

Pancuronium: Pancuronium, 1,1'-(3a,17/i-diacetoxy-5a-androstan-2/U6/i-ylene)-bis-(1-methylpiperidinium) dibromide (15.1.8), is synthesized from 3,17-bi's-(acetoxy)-2,16-5a-androstane. Oxidation with 3-chloroperbenzoic acid gives the bs-epoxy compound (15.1.5), the reaction of which with piperidine and subsequent hydrolysis gives an aminoketone (15.1.6). The keto group of the resulting compound (15.1.6) is reduced by sodium borohydride to hydroxyl group, giving the bis-aminoalcohol (15.1.7), subsequent acetylation of which by acetic anhydride and alkylation of both nitrogen atoms by methylbromide give the desired pancuronium (15.1.8) [12-14].




2. CH3Br

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