This complex, cardiostimulatory and vasodilating action is expressed by a significant increase of cardiac output and stroke volume. In response to activation of /¡2-adrenorecep-tors, bronchodilation also increases. Isoproterenol is used in bronchospasms, asthma, cardiac block, and shock. Synonyms of isoproterenol are proternol, isoprenaline, isadrine, norisodrine, novodrin, and others.
Isoetharine: Isoetharine, 3,4-dihydroxy-a-[1-(i,ro-propylamino)propyl]benzylic alcohol (11.1.11), differs from isoproterenol in the presence of an additional ethyl group in the ethyl-amino side chain—and is synthesized by bromination of 3,4-dibenzyloxybutyrophenone and the subsequent reaction of the resulting bromo derivative (11.1.9) with isopropylamine. The product (11.1.10) undergoes reduction by hydrogen using a palladium catalyst, during which the carbonyl group is simultaneously reduced and the benzyl-protecting group is removed, forming isoetharine (11.1.11) .
Isoetharine is a direct-acting sympathomimetic with relatively low selectivity with /¡2-adrenoreceptors. However, it quickly calms bronchospasms better than more selective bronchodilators. It is used in treating chronic obstructive illnesses of outer respiratory tract. Synonyms of this drug are asthmalitan and bronkosol.
Terbutaline: Terbutaline, a-[(ieri-butylamino)methyl]-3,5-dihydroxybenzylic alcohol (11.1.14), differs from the examined compounds mainly in the location of hydroxyl groups in the benzene ring, and is synthesized by brominating 3,5-dibenzyloxyace-tophenone into the appropriate 3,5-dibenzyloxybromoacetophenone (11.1.12), which is reacted with N-benzyl-N-ieri-butylamine, giving the aminoketone (11.1.13). Reduction of this product by hydrogen over a palladium catalyst leads to terbutaline (11.1.14)
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