Corticosteroids, synthetic steroid drugs made from the natural hormone hydrocortisone, and particularly prednisone, are frequently used for combination therapy for treating severe and chronic lymphocyte leukemia, Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and breast cancer. Corticosteroids exhibit an antitumor effect by binding with cor-ticosteroid receptors that exist in many cancerous lymphoma cells, which leads to inhibition of both glucose transport and phosphorylation, which reduces the amount of energy necessary for mitosis and protein synthesis, which, accordingly, leads to cell lysis.

30.5.5 Nonhormonal drugs

In addition to hormonal drugs, five other nonsteroids that have a direct relationship to this section are also used in cancer chemotherapy. They are aminoglutethimide, flutamide, mitotan, tamoxifen, and leuprolide.

Aminoglutethimide: Aminoglutethimide, (± )-2-(4-aminophenyl)-2-ethylglutarimide (30.5.4), is made by two methods, the first of which begins with glutethimide (4.3.6), which is nitrated to form 2-(4-nitrophenyl)-2-ethylglutarimide (30.5.3). Reducing the nitro group with hydrogen over a nickel catalyst gives the desired aminoglutethimide (30.5.4).



hno3/ h2so4

Was this article helpful?

0 0
Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook

Post a comment