Tolazoline is a weak, reversible a-adrenoblocker that lowers resistance of peripheral blood vessels and elevates venous capacity. However, it also exhibits ¡-adrenomimetic activity, which consists of the stimulation of cardiac work and is manifest as tachycardia, cholin-ergic activity, which consists of stimulation of the gastrointestinal tract, and histamine-like activity, which consists of stimulation of gastric secretion.
It is used for treating stable forms of pulmonary hypertension in newborns, and in cases where systemic arterial oxygenation cannot be achieved in the usual manner under careful observation of professionals. Synonyms of this drug are prixol, prixofen, imadalin, and others.
Phentolamine: Phentolamine, 2-[[N-(3'-hydroxyphenyl)-para-toluidion]methyl]-2-imidazoline (12.2.8), is synthesized by alkylation of 3-(4-methylanilino)phenol using 2-chloromethylimidazoline [36, 37].
/=\ C2H5OH Nh h2nch2ch2nh2 <^j>-ch2-cn »- / CH2-C-OC2H5 -»
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