This drug is used for preventing and treating thrombosis, thrombophlebitis, thromboe-molium, and for preventing thrombo-formation in post-operational periods. Synonyms of this drug are bishydroxycoumarin, dicumol, cromolyn, and others.

Ethyl biscoumacetate: Ethyl biscoumacetate, the ethyl ester of fe-(4-hydroxy-3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine, but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde [10-13].

This drug is used for the same indications as dicoumarin. Synonyms of this drug are neod-icoumarin, ethyldicourmarol, tremexan, dicumacyl, and others.

Warfarin: Warfarin, 3-(a-acetonylbenzyl)-4-hydroxycoumarin (24.1.10), is synthesized via Michael reaction by attaching 4-hydroxycoumarin (24.1.7) to benzalacetone in the presence of pyridine [14-19].

Warfarin is used as an anticoagulant for preventing and treating deep venous thromboses and pulmonary embolism. Synonyms of this drug are cumadin, panwarfin, sofrain, warnerin, and others.

Acenocoumarin: Acenocoumarin, 3-(a-acetonyl-p-nitrobenzyl)-4-hydroxycoumarin (24.1.11), is synthesized by a scheme completely analogous to making warfarin, but using p-nitrobenzalacetone [20].

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