Ethinamate is a hypnotic, which does not have, however, a considerable advantage over barbiturates and benzodiazepines, and is used much less in treating insomnia. Synonyms for this drug are valamide, ivalmad, valamin, and others.
Glutethimide: Glutethimide, 2-ethyl-2-phenylgutarimide (4.3.6), is synthesized by addition of 2-phenylbutyronitrile to the methylacrylate (Michael reaction), and the subsequent alkaline hydrolysis of the nitrile group in the obtained compound (4.3.5) into an amide group, and the subsequent acidic cyclization of the product into the desired glutethimide (4.3.6) [38-42].
Glutethimide is a hypnotic and sedative agent intended to treat insomnia. The hypnotic effect is roughly analogous to that of pentobarbital. It is given to patients who cannot
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