Cimetidine is a representative of first-generation antihistamine drugs that block H2 receptors. The main pharmacological effect of cimetidine is the suppression of gastric juice secretion associated with H2 receptors of the stomach walls. It suppresses both basal and stimulated hydrochloric acid produced by food as well as histamine and gastrine, which simultaneously lower pepsin activity.

Cimetidine is used for treating ulcer problems of the stomach and duodenum and for other conditions accompanied by an elevation of acidity and excess secretion of gastric juice. It is used for preventing injuries and the blood flow of the upper regions of the gastrointestinal tract. Synonyms of this drug are tagamet, cinamet, and belomet.

Ranitidine: Ranitidine, N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethendiamine (16.2.8), is synthesized from furfuryl alcohol, which undergoes aminomethylation reaction using dimethylamine and paraform, which form 5-(dimethylaminomethyl)furfuryl alcohol (16.2.6). Further reaction with 2-mercaptoethy-lamine hydrochloride gives a product of substitution of the hydroxyl group in (16.2.6), 5-dimethylaminomethyl-2-(2'-aminoethyl)thiomethylfurane (16.2.7). Reacting this with N-methyl-1-methylthio-2-nitroethenaamine gives ranitidine (16.2.8) [59-64].

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