Piperazine is an alternative drug and is used for treatment of various forms of nematodes, in particular for enterobiasis and ascariasis. It causes paralysis in the nematode by blocking acetylcholine transmission. This causes the parasite to detach from the mucous membrane, where it is removed from the body. Ascariasis requires treatment for 2 days, and enterobiasis, for 7 days. Synonyms of this drug are tasnon, uvilon, antepar, bexin, and many others.
Diethylcarbamazine: Diethylcarbamazine, N, N-diethyl-4-methyl-1-piperazincarboxamide (38.1.13), is made by acylating 1-methylpiperazine with diethylcarbamoylchloride [14-16].
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