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1. SOCl2

HO CH2 CH2 Cl CH2 CH2 NH2

CH2 CH COOH Cl CH2 CH2 NH2

Melaphalan is used intravenously and orally to treat multiple myeloma and cancers of the breast, neck, and ovaries. A synonym of this drug is alkeran.

The racemic form of this drug, D,L-3-[p-[bis-(2-chloroethyl)amino]phenyl]alanine, is also widely used under the name sarcolysine or racemelfalan.

Cyclophosphamide: Cyclophosphamide, 2-[bis-(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide (30.2.1.15), is made by reacting bis(2-chloroethyl)amine with phosphorous oxychloride, giving N,N-bis-(2-chloroethyl)dichlorophosphoramide (30.2.1.14), which upon subsequent reaction with 3-aminopropanol is transformed into cyclophosphamide (30.2.1.15) [51-59].

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