Info

12.2.4 CH2

12.2.5 ch2

12.2.5 ch2

Phenoxybenzamine is a /¡-chloroamine that is structurally related to alkylating agents used in chemotherapy. The mechanism of its long-lasting blockage of a-adrenoreceptors can evidently be explained by its irreversible alkylation. The irreversible blockage most likely occurs after briefly affecting a1- and a^adrenoreceptors. It is possible that the ¡-chlorethylamine region in tissue of the organism forms a highly reactive ethylenimo-nium intermediate, which then alkylates the receptor. Such blockages are irreversible and are called nonequilibrium receptor blockers.

Phenoxybenzamine is used in treating pheochromocytoma, swelling of the medullary layer of the adrenal glands, during which a large quantity of epinephrine is produced, which leads to a significant elevation of blood pressure. A synonym of this drug is diben-zyline.

Was this article helpful?

0 0
Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook


Post a comment