Info

2. ch3cosh c=c-ch2oh

2. ch3cosh scoch3

scoch3

Spironolactone is a potassium sparing diuretic that has a different mechanism of action than other drugs of this class.

It is a competitive antagonist of aldosterone, and its action is most effective when the level of circulated aldosterone in the organism is high.

oh aldosterone coch2oh aldosterone

Aldosterone is a mineralocorticosteroid that takes part in the regulation of electrolytic balance in the organism. Aldosterone lowers excretion of sodium ions from the body, thus increasing their reabsorption and increasing secretion of potassium ions in renal tubules. Being a competitive antagonist of aldosterone, spironlactone blocks aldosterone receptors, thus increasing excretion of sodium, chloride, and corresponding equivalents of water with urine, thus retaining the amount of potassium ions in the organism. Spironolactone is used both individually as well as in combination with thiazides, since it lowers kaliuresis caused by thiazide diuretics. It is used for edema syndrome caused by chronic cardiac insufficiency, liver cirrhosis, hyperaldosteronism, and hypokalemia caused by other diuretics. Synonyms of this drug are aldactone, verospirone, and others.

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