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Diphenhydramine also reduces muscle rigidity and general stiffness, and has a relatively minor effect on tremors.

Synonyms of this drug are benadryl and benylin.

Benztropine: Benztropine, 3-(diphenylmethoxy)tropane (10.2.6), is synthesized by the reaction of tropin and diphenyldiazomethane [38].

This drug is used for quick relief of severe distonic reactions in Parkinsonism. It does not relieve tremors. A synonym is congentin.

Ethopropazine: Ethopropazine, 10-(2-diethylaminopropyl) phenothiazine (10.2.7), is synthesized by alkylation of phenothiazine using 1-diethylamino-2-propylchloride in the presence of sodium amide [39,40].

Ethopropazine is a derivative of phenothiazine with expressed anticholinergic activity. It effectively reduces muscle rigidity and general stiffness, including tremors. It is used in Parkinson-ism as well as in other situations of extrapyramidal disorders, including situations caused by phenothiazine drugs. Synonyms of this drug are parsidol, lizivan, parcin, and others.

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