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Finally, there is one more suggested way of making 1-(2-phenyl-2-hydroxyethyl)-2-imino-1,3-thiazolidine (38.1.28), which consists of reacting 2-amino-1-phenylethanol with 2-bromoethylisothiocyanate. This leads to the direct formation of the key 1-(2-phenyl-2-hydroxyethyl)-2-imino-1,3-thiazolidine (38.1.28), which is transformed to tetramizole by a subsequent reaction with thionyl chloride, and then with acetic anhydride [37].

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