Colestipol binds to bile acids, which are secreted from the organism in a form which bunds to the ion-exchange resin. It lowers the overall level of cholesterol and cholesterol-containing low-density lipoproteins in blood plasma while not affecting the level of high-density lipoproteins. Colestipol is used for hypercholesterolemia (including atherosclerosis and arterial hypertension). Synonyms of this drug are colestabil, colestid, lestid, and others.
Cholestyramine: Cholestyramine (20.1.2) is a copolymer of divinylbenzene and styrene, which undergoes chloromethylation and afterwards is reacted with triethylamine .
CH2O / HCI
-ch-ch2~ch-ch2~ch-CH2_ —ch-ch2-ch—ch2-ch-ch2 —
CH2CI CH2CI CH2N(CH3)3 CH2N(CH3)3
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