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Colestipol binds to bile acids, which are secreted from the organism in a form which bunds to the ion-exchange resin. It lowers the overall level of cholesterol and cholesterol-containing low-density lipoproteins in blood plasma while not affecting the level of high-density lipoproteins. Colestipol is used for hypercholesterolemia (including atherosclerosis and arterial hypertension). Synonyms of this drug are colestabil, colestid, lestid, and others.

Cholestyramine: Cholestyramine (20.1.2) is a copolymer of divinylbenzene and styrene, which undergoes chloromethylation and afterwards is reacted with triethylamine [5].

CH2O / HCI

ch=ch2

CH-CH2—ch-ch2—CH-CH2— —ch-ch2—ch-ch2—ch-ch2—

(CH3)3N

CH2N(CH3)3 Cl_

-ch-ch2~ch-ch2~ch-CH2_ —ch-ch2-ch—ch2-ch-ch2 —

CH2CI CH2CI CH2N(CH3)3 CH2N(CH3)3

ci ci

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