Polythiazide exhibits a more pronounced antihypertensive effect than chlorothiazide and it may be used independently for the same indications as the aforementioned drugs. However, it is primarily used as an ingredient of a combination drugs intended for lowering pressure, in particular in minizide, which is a combination of prazozine and polythi-azide. Synonyms of this drug are drenusil, nephril, renis, and others.
There are a number of extremely important thiazide diuretics not listed above. These widely used drugs include hydroflumethiazid, trichlormethiazide, methylcyclothiazide, cyclothiazide, benzothiazide, diazoxide, and others, whose methods of synthesis and pharmacological action are practically identical to those listed above.
Hydroflumethiazid: Hydroflumethiazid, 1,1-dioxide 3,4-dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.9) [21,23-25].
Synonyms of this drug are leodrine, diuritens, hydrenox, riosyl, rontyl, diucardyn, calurin, salutenzine, and others.
Trichlormethiazide: Trichlormethiazide is 1,1-dioxide 3,4-dihydro-3-(dichlormethyl)-6-chloro-2#-1,2,4-benzothiadiazin-7-sulfonamide (21.3.10) [26-31].
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