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Mefloquine is an analog of quinine, and it differs from it in that the side chain at C4 of the quinoline ring contains a piperidine fragment instead of a quinuclidine fragment, and positions C2 and C8 are substituted with trifluoromethyl groups. This antimalarial drug was created to treat and prevent chloroquine resistance of malarial forms caused by P. falciparum. It is not clinically active against exoerythrocyte forms of P. vivax, although it is extremely active against blood schizontosides P. vivax and P. falciparum. It is intended to be used for treating weak and moderate forms of malaria caused by the indicated plasmodia. A synonym of this drug is lariam.

Quinghaosu (Artemisinine): Quinghaosu, octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano-(4,3-di)-1,2-benzodioxepin-10-(3#)-one (37.1.1.57), is isolated from the plant Artemisia annua [26].

It also has been made synthetically [27].

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