Ho

ohc o

Medroxyprogesterone: Medroxyprogesterone, 17a-hydroxy-6a-methylpregn-4-en-3,20-dione (28.3.7), differs from hydroxyprogesterone in the presence of an additional methyl group at C6, which was inserted in different ways [73-77].

It is used for the same indications as the drugs described above. Synonyms of this drug are amen, curretab, provera, and others.

Megestrol: Megestrol, 17a-hydroxy-6a-methylpregna-4,6-dien-3,20-dione acetate (28.3.9), is a product of dehydrogenation medroxyprogesterone (28.3.7) with chloranil (tetrachloro-p-benzoquinone) in the presence of p-toluenesulfonic acid, which results in the formation of an additional double bond at position C6-C7, and subsequent acetylation of the product (28.3.8) leads to the desired megestrol (28.3.9) by acetic anhydride in the presence of p-toluenesulfonic acid [78,79].

Was this article helpful?

0 0
Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook


Post a comment