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Medroxyprogesterone: Medroxyprogesterone, 17a-hydroxy-6a-methylpregn-4-en-3,20-dione (28.3.7), differs from hydroxyprogesterone in the presence of an additional methyl group at C6, which was inserted in different ways [73-77].

It is used for the same indications as the drugs described above. Synonyms of this drug are amen, curretab, provera, and others.

Megestrol: Megestrol, 17a-hydroxy-6a-methylpregna-4,6-dien-3,20-dione acetate (28.3.9), is a product of dehydrogenation medroxyprogesterone (28.3.7) with chloranil (tetrachloro-p-benzoquinone) in the presence of p-toluenesulfonic acid, which results in the formation of an additional double bond at position C6-C7, and subsequent acetylation of the product (28.3.8) leads to the desired megestrol (28.3.9) by acetic anhydride in the presence of p-toluenesulfonic acid [78,79].

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