Hn

Vecuronium is used for the same indications as pancuronium. A synonym of this drug is norcuron.

Atracurium: Atracurium is 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]] bis [1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquino-linium] dibenzene sulfonate (15.1.12). This compound is synthesized from bis-acrylic ester of 1,5-pentandiol (15.1.10), which is synthesized from acrylic acid chloride and 1, 5-pentandiol. Two molecules of a secondary amine, tetrahydropapaverine, are joined to the product in a Michael reaction, forming compound (15.1.11). Then both nitrogen atoms are methylated by methylbenzenesulfonate, giving atracurium (15.1.12) [17-19].

OCH3

H2C=CH-C-Cl + HO-(CH2)5-OH -»- H2C=CH-C — O-(CH2)5-O—C-CH =CH2

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