Cycloserine has a broad spectrum of antibacterial use. It is active against both Gram-positive and Gram-negative bacteria as well as against tuberculosis mycobacteria that are resistant to drugs of the first group. It acts bactericidally, disrupting the synthesis of mycobacterial cell membranes. The accepted explanation behind this is its chemical affinity with D-alanine, which allows it to competitively suppress activity of the enzyme D-alaninracemase and D-alaninesynthetase, which results in the disruption of D-alanyl-D-alanine formation, which is necessary for building cell membranes in bacteria. Cycloserine is used for treating patients with chronic forms of tuberculosis who did not respond to treatment of drugs of the first group. Synonyms of this drug are cyclovaldin, cyclomycin, seromycin, and others.
Capreomycin: Capreomycin is a semisynthetic antibiotic (34.1.21) that is isolated from the cultural fluid of Streptomyces capreolus, and it is a complex of a minimum of four microbiologically active ingredients that have only partially been characterized. Capreomycins IA and IB are represented below.
Was this article helpful?