Imipramine is the primary representative of typical tricyclic antidepressants. It acts by blocking the mechanism of reuptake of biogenic amines. It does not inhibit MAO activity. Imipramine lessens sadness, lethargy, improves mood, and improves the mental and overall tone of the body. It is used in depression of various etiology accompanied by motor clumsiness and enuresis in children and Parkinson's disease. Primary synonyms of this drug are tofranil, surplix, imizin, melipramin, and others.
Trimipramine: Trimipramine, 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f|-azepine (7.1.2), is synthesized in the exact manner as imipramine, alkylating 10,11-dihydro-5H-dibenz[b,f]azepine with 3-dimethylamino-2-methylpropylchloride [4,5] instead of 3-dimethylaminopropylchloride, as it was in the case of imipramine.
As with imipramine, it is used for depression of various etiology. In terms of efficacy, it is analogous to imipramine. Surmontil is a synonym of trimipramine.
Amitriptyline: Amitriptyline, 5-(3-dimethylaminopropyliden)-10,11-dihydrodibenzocy-cloheptene (7.1.4), differs from imipramine in that the nitrogen atom in the central part of the tricyclic system is replaced by a carbon, which is bound to a side chain by a double bond. Amitriptyline (7.1.4) is synthesized by interaction of 10,11-dihydro-N,N-dimethyl-5H-dibenzo[a,d]cyclohepten-5-one with 3-dimethylaminopropylmagnesium bromide and the subsequent dehydration of the resulting tertiary alcohol (7.1.3) using hydrochloric acid [6-11].
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