Isoproterenol: Isoproterenol, 1-(3,4-dihydroxyphenyl)-2-iso-propylaminoethanol (11.1.8), is synthesized by an analogous scheme of making epinephrine. Interaction of fö-chloro-3,4-dihydroxyacetophenone (chloroacetylpyrocatechol) with isopropylamine gives fö-isopropy-lamino-3,4-dihydroxyacetophenone (11.1.7), reduction of the carbonyl group of which by hydrogen using a palladium on carbon catalyst gives isoproterenol (11.1.8) [11,12].
Isoproterenol is a representative of the sympathomimetic drugs with high selectivity to (-adrenoreceptors. As was already noted, the addition to compounds of a bulky wopropyl or ieri-butyl group at the nitrogen atom of the (-phenylethylamino skeleton is associated with higher affinity to (-adrenergic receptive regions than to a-adrenergic. Isoproterenol is devoid of significant a-adrenergic agonistic action. Activation of (^-adrenergic receptors in the heart increases positive chronotropic and ionotropic action. Peripheral vascular resistance is increased by the widening of blood vessels, primarily in skeletal muscle, but also in renal and mesenteric blood circulation, which is caused by the (2-adrenergic system.
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