Vinblastine and vincristine are alkaloids isolated from plants of the periwinkle family (Vinca rosea). These compounds cause cells to stop at metaphase and inhibit assembly of microtubules, and likewise, failure of mitotic spindle formations. They inhibit synthesis of nucleic acids and proteins.
Vinblastine and vincristine differ only in the substituent on the nitrogen atom of the indol fragment of the molecule, and are used in combination with other chemotherapeutic agents. They are mainly used for leukoses, myelomas, sarcomas, cancer of various organs, and for lymphomas.
Vinblastine: Vinblastine, [3aR-[3aa,4^,5^,5a^,9(3R*,5S*,7R*,9S*),10bR*,13aa]]methyl-4-(acetyloxy)-9-[5-ethyl1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino-[5,4=b]indol-9-yl]-3a-ethyl-,4,5,5a,6,11,12,13a-octahydro -5-hydroxy-8-methoxy-6-methyl-1H-indolizino [8,1-cd]-carbozol-5-carboxylate (30.4.1), is isolated from V. rosea [117-120].
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