Ci

Triethylenthiophosphoramide is used intravenously in early stages of liver, uterine, and breast carcinomas. It is used for chronic lymphatic leukemia, lymphogranulomatosis, and lymphosarcomatosis. It is used for reducing the number of reoccurances and metastases, and in complex treatment of various forms of cancer. Synonyms of this drug are tespamin, tilphophamid, thiophosil, and others.

30.2.3 Alkyl sulfonates

Busulfan is the one drug in the alkylsulfonate series used in medicine.

Busulfan: Busulfan, 1,4-butandioldimethansulfonate (30.2.3.1), is made by reacting butandiol with methanesulfonyl chloride [65,66].

ch2-ch2-oh + 2ch s0c|^ 0h2-ch2-o-so2-ch3 ch2-ch2-oh 3 2 ch2-ch2-o-so2-ch3

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