Ch3

Amitriptyline is used for anxious-depressive conditions. It is easier to tolerate than imipramine. The most frequently encountered synonyms are triptizol and amiprin.

Doxepin: Doxepin, (11[16H]-(3-dimethylaminopropyliden)-6,11-dihydrobenz[b,e] oxepine) (7.1.11), is synthesized in an analogous manner by reacting 6,11-dihydrodibenz-[b,e]oxepin-11-one (7.1.9) with 3-dimethylaminopropylmagnesium bromide and the subsequent dehydration of the resulting tertiary alcohol (7.1.10) by hydrochloric acid [14-17].

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