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Tolnaftate is used as an external drug for moderate dermatophyte infections (shingles), and it is not effective for treating candida infections. Synonyms of this drug are tinatox, tonof-tal, timoped, tinaderm, tinactin, and others.

Haloprogin: Haloprogin, 3-iodo-2-propinyl-2,4,5-trichlorophenyl ether (35.4.11), is synthesized by an iodide substitution using a mixture of iodine and potassium iodide and a cupric derivative of 2,4,5-trichlorophenylpropargyl ether (35.4.10), which is synthesized by a standard method from propargyl bromide and 2,4,5-trichlorophenol in the presence of sodium hydroxide [65-67].

NaOH 2.12 / KI Cl—V y— OH + Br-CHjjCECH-»-Cl—V y-O-CH2CECH -»-Cl—P y-O-CH2C=C—I

Haloprogin is used as an external drug for moderate dermatophyte infections (shingles), and it is effective for superficial candida infections. Synonyms of this drug are halotex, mycilan, micanden, and others.

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