Ch2c6h5

ch3ooc ch3ooc h_n, ch3ooc

HO—^ à +CL-C-CH2-Br—>■ HO—^ ))—C-CH2—Br-»- HO—^ A— C-CH2—N

11.1.27 11.128

LiAlH4

HO—^ à +CL-C-CH2-Br—>■ HO—^ ))—C-CH2—Br-»- HO—^ A— C-CH2—N

11.1.27 11.128

Albuterol is a /¡2-adrenergic sympathomimetic amine with pharmacological similarities to terbutaline. It has almost no effect on /¡radrenoreceptors of the heart. It has expressed broncholytic effects—prevention or relief of bronchi spasms, lowering respiratory tract resistance, and increasing the vital capacity of the lungs.

It is widely used for severe and chronic bronchial asthma and other illnesses of the respiratory tract that result in a spastic condition of the bronchi. Synonyms of albuterol are aloprol, ventolin, volma, salbutamol, salbuvent, spreor, and others.

Dobutamine: Dobutamine, (±) 4-[2(4'-hydroxyphenyl)-1-methylpropyl]-3,4-dihydrox-yphenylethylamine (11.1.31), differs significantly from all of the presented drugs in terms of structure, the main difference being the absence of a hydroxyl group at the /¡-carbon atom of the phenylethylamine moiety of classic sympathomimetics. The second considerable difference from the examined drugs is the presence of p-hydroxyphenyl-iso-buty-lamine group as a terminal amine substituent.

It is synthesized by the reaction of 3,4-dimethoxyphenyl-2-amine and 1-(4-methoxyphenyl)-3-butanone with a simultaneous reduction of formed imine, giving the product (11.1.30), the methoxyl-protecting groups of which are cleaved by hydrogen bromide, giving dobutamine (11.1.31) [32,33].

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