Carbamazepine

Carbamazepine: Carbamazepine, 5H-dibenz[b,f]azepine-5-carboxamide (9.5.2), is synthesized by reacting 5H-dibenz[b,f]azepine and phosgene, which forms 5-chlorcarboxy-5H-dibenz-[b,f]azepine (9.5.1), and its subsequent reaction with ammonia to give the desired carbamazepine (9.5.2) [16]. An alternative method of synthesis is the direct reaction of 5H-dibenz[b,f]azepine with potassium cyanate [17].

Carbamazepine is used principally for major epileptic attacks. It is not effective enough for minor attacks. There are data showing a number of side effects. A synonym of carba-mazepine is tegretol.

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