Antibiotics

A number of antibiotics possess pronounced cytostatic properties, and they are extremely effective in treating certain tumors. Included in this group are actinomycin, anthracyclins (daunorubicin and doxorubicin), bleomycin, and others.

A few of them, not including mitoxanthrone, which is a purely synthetic drug, are made microbiologically, and a few of them, whose syntheses are included in the reference literature, have also been developed synthetically. In this chapter, only their structure and indications for use will be examined.

30.3.1 Dactinomycines

Dactinomycin: Dactinomycin, 2-amino-1,9-bis-(2,9-diisopropyl-6,10,13-trimethyl-1,4,8,11,14-pentaoxo-7-oxa-3,10,13-17a-tetraaza-5-bicyclo[14.3.0]nonadecylcarbamoyl)-4,6-dimethyl-3H-phenoxazin-3-one (30.3.1), is one of the first antibiotics isolated from a liquid culture of microorganisms of the family Streptomyces parvulus [80-87]. It is a chromonopeptide with a phenoxazine ring and two cyclic polypeptides joined to the car-boxyl group at position 2 and 9 of the phenoxazine ring.

ch3 ch3

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