A number of antibiotics possess pronounced cytostatic properties, and they are extremely effective in treating certain tumors. Included in this group are actinomycin, anthracyclins (daunorubicin and doxorubicin), bleomycin, and others.
A few of them, not including mitoxanthrone, which is a purely synthetic drug, are made microbiologically, and a few of them, whose syntheses are included in the reference literature, have also been developed synthetically. In this chapter, only their structure and indications for use will be examined.
Dactinomycin: Dactinomycin, 2-amino-1,9-bis-(2,9-diisopropyl-6,10,13-trimethyl-1,4,8,11,14-pentaoxo-7-oxa-3,10,13-17a-tetraaza-5-bicyclo[14.3.0]nonadecylcarbamoyl)-4,6-dimethyl-3H-phenoxazin-3-one (30.3.1), is one of the first antibiotics isolated from a liquid culture of microorganisms of the family Streptomyces parvulus [80-87]. It is a chromonopeptide with a phenoxazine ring and two cyclic polypeptides joined to the car-boxyl group at position 2 and 9 of the phenoxazine ring.
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