Moisture Adsorption

Moisture adsorption by solid dosage forms can result not only in increased chemical drug degradation but also in changes in the functional stability of dosage forms.

A hard gelatin capsule exhibited moisture sorption depending on humidity, the hysteresis of which was analyzed by the Young-Nelson hypothesis. This allowed the formation of a monolayer of adsorbed moisture to be distinguished from normal condensation of moisture and from absorption of moisture (Fig. 185).728

Figure 187. Arrhenius plots for discoloration of parenteral formulations of ascorbic acid (1), reserpine (2), thiamine hydrochloride (3), and ATP (4). The parameters k and m represent the constants obtained using the Weibull equation (time unit: day). (Reproduced from Ref. 730 with permission.)

Figure 187. Arrhenius plots for discoloration of parenteral formulations of ascorbic acid (1), reserpine (2), thiamine hydrochloride (3), and ATP (4). The parameters k and m represent the constants obtained using the Weibull equation (time unit: day). (Reproduced from Ref. 730 with permission.)

The moisture permeation rate of a sugar coating composed of sucrose, talc, and other minor components was reported to conform to Fick's equation.729 The permeation rate appeared to be rate-controlling for moisture adsorption by sugar-coated tablets.

Moisture adsorption of dosage forms in relation to the moisture permeation ofpackaging will be described in Section 4.3.1.

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