product 2

0 6 12 18 24 storage time (month)

Figure 175. Changes in the melting time of suppositories following storage at 20°C. (Reproduced from Ref. 707 with permission.)

Changes in melting properties during storage were also reported for effervescent suppositories even when stored at 25°C; this indicated that these products should be stored below 15°C (Fig. 178)™

Continue reading here: Changes in Drug Release Rate from Polymeric Matrix Dosage Forms Including Microspheres

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