Changes in Mechanical Strength

Storage of solid dosage forms under humid conditions may bring about adsorption of moisture and lead to changes in the mechanical strength of tablets.665-669 Adsorption of moisture by tablets in blister packages increased with increasing humidity, and resulted in decreased mechanical strength (Fig. 162).668 The change in mechanical strength was described as a function of the moisture sensitivity of the tablet, the moisture permeability of the package, and the humidity conditions. Knowledge of the dependency on each of these factors allowed prediction of the long-term storage properties of the product. A close correlation was seen between calculated and observed properties.668

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Figure 162. Moisture adsorption (a) and strength change (b) of model tablets stored in blister packages maintained at 21-22°Cand varying relative humidities, a. 25% RH. □. 60% RH; 70% RH; o. 95%RH. (Reproduced from Ref. 668 with permission.)

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Figure 162. Moisture adsorption (a) and strength change (b) of model tablets stored in blister packages maintained at 21-22°Cand varying relative humidities, a. 25% RH. □. 60% RH; 70% RH; o. 95%RH. (Reproduced from Ref. 668 with permission.)

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