Drug interactions The safety of the thrombolytic drug alteplase (tPA) plus clomethiazole in patients with acute ischemic stroke has been assessed in a randomized, double-blind study (22C). All received alteplase 0.9 mg/kg beginning within 3 hours of stroke onset and then either intravenous clomethiazole 68 mg/kg

(n = 97) over 24 hours, or placebo (n = 93) beginning within 12 hours of stroke onset. During follow-up for 90 days the number of serious adverse event reports was 47 in the clomethiazole group and 48 in the placebo group. There were 15 deaths in those given clomethiazole and nine in those given placebo, but this was not significantly different. Sedation was also greater with clomethiazole (42%) than placebo (13%).

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