Methods and Principles in Medicinal Chemistry

Edited by R. Mannhold H. Kubinyi H. Timmerman

Editorial Board

C. Folkers, H.-D. Holtje,J. Vacca, H. van de Waterbeemd, T. Wieland

Bioinformatics - From Genomes to Drugs

Volume I: Basic Technologies Volume II: Applications

Edited by Thomas Lengauer


Series Editors

Prof. Dr. Raimund Mannhold

Biomedical Research Center Molecular Drug Research Group Heinrich-Heine-Universität Universitätsstraße 1 D-40225 Düsseldorf Germany

Prof. Dr. Hugo Kubinyi

BASF AG, Ludwigshaften c/o Donnersbergstrasse g D-67256 Weisenheim am Sand Germany

Prof. Dr. Gerd Folkers

Department of Applied Biosciences

ETH Zürich

Winterthurer Str. 190

CH-8057 Zürich


Volume Editor:

Prof. Dr. Thomas Lengauer, Ph.D.

Fraunhofer Institute for Algorithms and Scientific Computing (SCAI) Schloss Birlinghoven D-53754 Sankt Augustin Germany

■ This book was carefully produced.

Nevertheless, editors, authors and publisher do not warrant the information contained therein to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.

Library of Congress Card No.: applied for

A catalogue record for this book is available from the British Library. Die Deutsche Bibliothek - CIP Cataloguing-in-Publication-Data A catalogue record for this publication is available from Die Deutsche Bibliothek

© Wiley-VCH Verlag GmbH, Weinheim (Federal Republic of Germany). 2002 All rights reserved (including those of translation in other languages). No part of this book may be reproduced in any form - by photoprinting, microfilm, or any other means - nor transmitted or translated into machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law.

Printed in the Federal Republic of Germany.

Printed on acid-free paper.

Typesetting Asco Typesetters, Hong Kong

Printing betz-druck GmbH, Darmstadt Bookbinding J. Schaffer GmbH & Co. KG, Grunstadt

ISBN 3-527-29988-2

Continue reading here: Preface

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