Lam

Comparison of native and modelled repressor-DNA complexes. Superposition of native (black) and modelled (grey) complexes. The DNA is shown as the phosphate backbone with lines for the

Comparison of native and modelled repressor-DNA complexes. Superposition of native (black) and modelled (grey) complexes. The DNA is shown as the phosphate backbone with lines for the

base pairs. The repressor is shown as a Ca trace. The first correct structure from Table 8.3 is shown. For MET the best model is described. Reproduced with permission from Figure 8.2 of Aloy et al. [34].

are obtaining for protein-protein docking. The method therefore would have to be used cautiously, for example in systems where there is substantial experimental data or when experiments would be designed to evaluate the prediction. In addition, the repressor-DNA system studied has limited conformational change on complex formation and many systems exhibit far larger changes in structure. In general, one does not know of the extent of conformational change on complex formation in advance of knowing the structure.

Continue reading here: Evaluation of the results of docking simulations

Was this article helpful?

0 0