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MAO INHIBITORS Many psychoactive drugs j are either classified as MAO inhibitors or else j interact profoundly with such drugs. Because they ^

depress the action of monoamine oxidase (MAO). j an important body enzyme that breaks down )

certain amines and renders them harmless, they "]

should not be taken with any of the great variety ]

of substances that contain these amines. \

Tyramine. a common substance in many foods \

that is usually metabolized with little or no effect, i may become dangerous when taken in I

combination with an MAO inhibitor-causing 1

intense headache, high blood pressure, vomiting ■

and possibly death. Tyramine is present in wine. i beer, yeast extract, avocados, bananas, aged \

cheeses, wild fennel and in most of the drinks j with caffeinelike alkaloids. \

MAO inhibitors often intensify or modify the ]

effects of drugs such as amphetamines, eNS j depressants (barbiturates, tranquilizers, sedatives, j

The Witch by Hans WeidiU

THE ACID BABIES "In regard to chromosome damage, we desigiied experiments to find out if there was any. These turned out to be completely negative In regard to the possible damage to children conceived during an LSD trip and to a pregnant mother taking LSD. we had lots of examples of people in the early days who were on psychotherapeutic regimes with LSD and who coiKeived and produced babies while taking LSD. I know of these children today and they are reaUy delightful people. There is no sign of damage whatsoever."

John LQly

Tfie Center of /fie Cyclone, 1973

LSD One of the most potent drugs ever discovered. LSD was first synthesized by Dr. Albert Hofmann at the Sandoz Laboratories in Basel, Switzerland, in 1938. Dr. Hoffmann's description of his experiences after he ingested a small quantity of the substance is probably one of the best known accounts of an individual drug episode. In the past. LSD has been used with some success in treating alcoholism and opiate addiction, psychiatric problems (especially autistic children), frigidity and homosexuality. Some very interesting experiments were conducted with leiminal cancer patients who hypnotics), blood pressure medications, antidepressants, narcotic analgesics, insulin, antihistamines, reserpine, epliedrine and others by altering their metabolism. Many substances ordinarily absorbed quickly by MAO remain in the sysiem for extended periods of lime when this enzyme is suppressed. The mechanism of these interactions is not completely understood because there are so many complex variables. Therefore MAO-inhibiting substances should be used with exireme caution. In addition, some MAO inhibitors remain active in the body for up to several weeks after ingestion.

Hallucinogens such as yohimbe, the liarmaline alkaloids and various tryptamines are very potent MAO inhibitors, although shon-actir\g. Antidepressants (the nonstimulant kind) and blood pressure medications are often MAO inhibitors.

OTC REMEDIES Some psychoactive drugs, albeit tame ones, are not only available without prescription, they are constantly puffed, promoted and recommended in virtually every advertising medium in the country. Most of the OTC stimulants are simply high-priced caffeine. A NoDoz tablet contains 100 mg. of caffeine, about as much as a cup of brewed coffee, and it will be more stimulating only if one is susceptible to shiny packaging and high-powered suggestion.

Although variously hawked as "sleeping aids," "tranquilizers" and "calmatives," most OTC sedatives use an antihistamine as their active ingredient. .

PARALDEHYDE Discovered in 1829 and introduced into medicine as a soporific in 1884, paraldehyde is a colorless, highly inflammable liquid with a pungent odor and very unpleasant taste. These attributes have caused the liquid to be phased out of medicine. In pill form, however, the drug is still used in cases where barbiturates cannot be tolerated. A brand currently available is Para I,

In terms of potential addiction, tolerance and withdrawal, , paraldehyde is generally lbought of as being somewhere between alcohol and chloral hydrate. It is considered slightly more intoxicating than barbiturates or al<;phol. .

PEMOLINE AND PEMOLINE MAGNESIUM Discovered in 1913, pemoline was found to have nervous stimulant properties in the mid-1950s. The magnesium form of the drug is alleged to aid both the retention of new and the recall, of old information, especially, in combination with a high protein diet with proper vitamin (especially B complex and C) and mineral intake.

For use as a memory, drug, a dosage of 50 mg. per day for 20-day periods with a month's rest in between is best.. Memory may be enhanced by as much as 60 percent in both young people and the old and senile. Abbott Laboratories is currently studying this drug in regard to learning and memory: It is postulated that pemoline magnesium works either by stimulating formation of R.NA in the brain or by carrying magnesium, which serves as a natural catalyst-conductor in memory1 circuits.

PHENCYCLIDINE (PCP) Although at one time marketed for human use by Parke-Davis under the name Setnylan and chemically similar to the hypnotic Doriden, this analgesic-anesthetic is used only in veterinary medicine these days. Known as "PCP," "angel dust," "hog," "elephant," "peace powder," and many other sobriquets, this stuff often appears at parties in capsules, as a powder or1 impregnated in marijuana, oregano or parsley. Sometimes foisted as "THC," PCP will give highs that vary from a pleasant distortion of reality to a nauseating semicoma.

PCP actually has a small cult, following whose devotees enjoy the combination psychedelic-anesthetic. head. While the drug can pioduce entertainingly strange effects, many people don't like it because it is very easy to overdo. A little too much of this stuff' going around can turn a roaring party into a room f ■. i of zombies lying on the carpet unable to move so much as an eyelid, Other effects from an overdose can include muscle spasms, vomiting, disorientation. headache, agitation and a terrible feeling that you've damaged sensitive inner structures.

[-\|- i. i irn Opii (0.. S. el a], Plil-I-vtr.il( of Opium.

Take of Opium 12 ounccs,

Mncemtc Ihc opium in I pint of water for lvvcnl> till (lom-s, and express the liquid. Treat it iu Iil-t manner with each of the 4 pints» of waier remaining, mix tltc liquids, filter, and cvapovatc to a, pi lie cousistencc. Dose: it lo 1 grain.

Tiicc of Opium 24. Myitis.

Beal togclhcr with water, and d ividc into 24. pills. I'osc: I pill..

Suppositoria <^>ii (0.. S.)-SupposiIorics of <^>ium.

Take of Extract, of opiu.n 12 gmirts.

Oil of iheobromu. 34H grains.

Rub hit rvi-j. 1 inio a smooth., paste Willi water. i'k-ii mix with I dcictim of llie oil„ and leaving-- niello.} Ilie remainder und cooled il to IV,

Etcerpi from Johnson Medical Formulary of 1884

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